TRA2A

Across TCGA cell cohorts, TRA2A RNA expression is significantly associated with the go_rna of many other GO terms, with 3,943 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible TRA2A-associated GO terms across cancer lineages are Heterochromatin organization, Positive regulation of double-strand break repair, and Negative regulation of gene expression, epigenetic. Each is linked with TRA2A in more than 14 cancer types. Because this analysis shows association rather than direction, both TRA2A-to-partner and partner-to-TRA2A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Heterochromatin organization grouped by TRA2A-low versus TRA2A-high in LARGE_INTESTINE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TRA2A→partner) and Y-score (partner→TRA2A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	Heterochromatin organization →	+0.058	+0.644	<.001	<.001	3	15
UPPER_AERODIGESTIVE_TRACT	Positive regulation of double-strand break repair →	+0.080	+1.110	<.001	<.001	3	14
STOMACH	Negative regulation of gene expression, epigenetic →	+0.069	+0.480	.002	.002	3	14
LUNG_SCLC	Microtubule organizing center organization →	+0.089	+0.663	<.001	<.001	3	13
PANCREAS	Regulation of RNA splicing →	+0.076	+0.436	<.001	.002	3	13
LUNG_SCLC	Centrosome cycle →	+0.097	+0.662	<.001	<.001	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,943 associations by consensus.

Heterochromatin organization by TRA2A expression — LARGE_INTESTINE

Explore this box plot interactively →