TRA2A

Across TCGA cell cohorts, TRA2A mutation is significantly associated with the RNA expression of many other genes, with 4 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TRA2A-associated genes across cancer lineages are DEFA4, COL6A5, and OR6Q1. Each is linked with TRA2A in more than 1 cancer types. Because this analysis shows association rather than direction, both TRA2A-to-partner and partner-to-TRA2A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DEFA4 grouped by TRA2A-low versus TRA2A-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TRA2A→partner) and Y-score (partner→TRA2A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	DEFA4 →	+0.022	+3.700	<.001	.009	3	1
LARGE_INTESTINE	COL6A5 →	+0.409	+3.724	<.001	.004	3	1
LARGE_INTESTINE	OR6Q1 →	+0.012	+3.700	<.001	.009	3	1
LARGE_INTESTINE	CLEC18C →	+0.166	+3.333	<.001	.009	1	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

DEFA4 by TRA2A expression — LARGE_INTESTINE

Explore this box plot interactively →