TPX2

protein abundance — cross-omics
Cross-omicsPROTEIN-MS → RNAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, TPX2 protein abundance is significantly associated with the RNA expression of many other genes, with 20,120 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible TPX2-associated genes across cancer lineages are MYBL2, E2F1, and FAM83D. Each is linked with TPX2 in more than 8 cancer types. Because this analysis shows association rather than direction, both TPX2-to-partner and partner-to-TPX2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, TPX2 versus MYBL2 in LUAD, with a Pearson correlation of 0.73.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TPX2→partner) and Y-score (partner→TPX2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
LUADMYBL2 →+1.902+1.015<.001<.00139
LUADE2F1 →+1.462+0.999<.001<.00139
BRCAFAM83D →+1.513+0.968<.001<.00139
HNSCEZH2 →+1.216+0.607<.001<.00139
BRCACDCA3 →+1.261+0.928<.001<.00139
UCECFBXO5 →+0.882+0.979<.001<.00139
Each partner links to its Q-omics profile. Showing the 6 strongest of 20,120 associations by consensus.

TPX2 vs MYBL2 — LUAD

Per-sample scatter of TPX2 vs MYBL2 in LUAD (Pearson r = 0.73).

Explore this scatter interactively →

Exploration