TPTEP1

Across TCGA patient cohorts, TPTEP1 mutation is significantly associated with the total protein of many other genes, with 14 significant associations in total. COAD shows the largest number of these associations.

The most reproducible TPTEP1-associated genes across cancer lineages are Tuberin, 4E-BP1, and C-Raf. Each is linked with TPTEP1 in more than 1 cancer types. Because this analysis shows association rather than direction, both TPTEP1-to-partner and partner-to-TPTEP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Tuberin grouped by TPTEP1-low versus TPTEP1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TPTEP1→partner) and Y-score (partner→TPTEP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Tuberin →	+0.441	+3.009	.002	.019	3	1
UCEC	4E-BP1 →	+0.435	+3.029	.003	.018	3	1
UCEC	C-Raf →	+0.204	+3.169	.009	.020	3	1
COAD	eIF4G →	-0.706	-2.313	.007	.035	3	1
COAD	PDCD4 →	-0.608	-3.169	.001	.018	2	2
COAD	PDK1_pS241 →	-0.237	-3.157	.001	.018	2	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

Tuberin by TPTEP1 expression — UCEC

Explore this box plot interactively →