TPTE2P5

Across TCGA pan-cancer cohorts, TPTE2P5 RNA is linked to patient survival in 26 of 34 cancer types, making it the most broadly survival-associated TPTE2P5 data layer.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher TPTE2P5 RNA is associated with better overall survival. In most high-consensus cancer types, elevated TPTE2P5 expression acts as an unfavorable survival marker, although some lineages such as HNSC and BLCA show a favorable association.

HNSC, BLCA, and UVM are the cancer types where TPTE2P5 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Tertile	III,IV	0.439	0.231	.001	99	view →
BLCA	OS	Quartile	II,III,IV	0.727	0.534	<.001	70	view →
UVM	DFS	Quartile	All	0.330	0.808	.004	42	view →
GBM	DFS	Median	All	0.396	0.186	.003	31	view →
SARC	DFS	Tertile	All	0.728	0.512	<.001	29	view →
COAD	OS	Median	IV	0.703	0.381	.002	23	view →
BRCA	OS	Quartile	III,IV	0.984	0.811	<.001	18	view →
STAD	DFS	Tertile	All	0.717	0.560	.015	17	view →
LGG	OS	Tertile	All	0.951	0.839	<.001	16	view →
LIHC	OS	Median	II,III,IV	0.872	0.644	.008	15	view →
UCEC	OS	Quartile	All	0.982	0.897	.003	14	view →
READ	OS	Tertile	II,III,IV	0.745	0.300	.005	13	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

TPTE2P5–HNSC (OS)

Open the HNSC breakdown →