TPTE2P2

Across TCGA patient cohorts, TPTE2P2 mutation is significantly associated with the RNA expression of many other genes, with 434 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TPTE2P2-associated genes across cancer lineages are NDUFAF5, PIGU, and NKAP. Each is linked with TPTE2P2 in more than 1 cancer types. Because this analysis shows association rather than direction, both TPTE2P2-to-partner and partner-to-TPTE2P2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NDUFAF5 grouped by TPTE2P2-low versus TPTE2P2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TPTE2P2→partner) and Y-score (partner→TPTE2P2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	NDUFAF5 →	+0.565	+3.397	<.001	.004	3	1
UCEC	PIGU →	+0.499	+3.364	.004	.005	3	1
UCEC	NKAP →	+0.509	+3.332	.003	.005	3	1
UCEC	HMOX2 →	+0.541	+3.343	.001	.005	3	1
UCEC	UBXN8 →	+0.677	+3.332	.005	.005	3	1
UCEC	LSM5 →	+0.585	+3.386	.007	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 434 associations by consensus.

NDUFAF5 by TPTE2P2 expression — UCEC

Explore this box plot interactively →