TPTE2

Across TCGA patient cohorts, TPTE2 mutation is significantly associated with the total protein of many other genes, with 57 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TPTE2-associated genes across cancer lineages are ATM, Shc_pY317, and Cyclin-E2. Each is linked with TPTE2 in more than 3 cancer types. Because this analysis shows association rather than direction, both TPTE2-to-partner and partner-to-TPTE2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by TPTE2-low versus TPTE2-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TPTE2→partner) and Y-score (partner→TPTE2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	ATM →	-0.681	-3.000	<.001	.034	3	4
COAD	Shc_pY317 →	-0.181	-3.161	.029	.019	3	3
COAD	Cyclin-E2 →	+0.225	+2.832	.049	.034	3	3
UCEC	Caspase-7-cleavedD198 →	+0.642	+2.412	<.001	<.001	3	3
COAD	mTOR_pS2448 →	-0.193	-3.161	.029	.019	2	3
COAD	PDCD4 →	-0.629	-3.000	.002	.035	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 57 associations by consensus.

ATM by TPTE2 expression — COAD

Explore this box plot interactively →