TPTE2

Across TCGA cell cohorts, TPTE2 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,310 significant associations in total. BONE shows the largest number of these associations.

The most reproducible TPTE2-associated GO terms across cancer lineages are Regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway, Regulation of cytoplasmic mRNA processing body assembly, and Positive regulation of hematopoietic stem cell proliferation. Each is linked with TPTE2 in more than 5 cancer types. Because this analysis shows association rather than direction, both TPTE2-to-partner and partner-to-TPTE2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway grouped by TPTE2-low versus TPTE2-high in KIDNEY.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TPTE2→partner) and Y-score (partner→TPTE2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	Regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway →	+0.165	+0.117	<.001	.003	3	6
BONE	Regulation of cytoplasmic mRNA processing body assembly →	+0.099	+3.211	<.001	<.001	3	4
BONE	Positive regulation of hematopoietic stem cell proliferation →	+0.098	+2.955	.001	<.001	3	4
BONE	Regulation of phospholipid efflux →	+0.963	+1.838	<.001	.004	3	4
BONE	Positive regulation of phospholipid efflux →	+0.963	+1.838	<.001	.004	3	4
SOFT_TISSUE	COPII-coated vesicle budding →	+0.048	+0.026	.004	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,310 associations by consensus.

Regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway by TPTE2 expression — KIDNEY

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