TPTE2

Across TCGA cell cohorts, TPTE2 mutation is significantly associated with the RNA expression of many other genes, with 40 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TPTE2-associated genes across cancer lineages are CUX2, OR9Q1, and SLC10A1. Each is linked with TPTE2 in more than 1 cancer types. Because this analysis shows association rather than direction, both TPTE2-to-partner and partner-to-TPTE2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CUX2 grouped by TPTE2-low versus TPTE2-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TPTE2→partner) and Y-score (partner→TPTE2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	CUX2 →	+0.035	+3.082	.004	.005	3	2
BREAST	OR9Q1 →	+0.013	+5.169	<.001	.005	3	1
SKIN	SLC10A1 →	+0.034	+3.520	.005	.005	3	1
SKIN	SCGB3A2 →	+0.060	+3.217	<.001	.006	3	1
SKIN	TOPAZ1 →	+0.005	+3.700	<.001	.009	3	1
SKIN	CD300E →	+0.013	+3.115	.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 40 associations by consensus.

CUX2 by TPTE2 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →