TPST1

Across TCGA patient cohorts, TPST1 mutation is significantly associated with the RNA expression of many other genes, with 748 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TPST1-associated genes across cancer lineages are RNU1-17P, RNU6-1060P, and RNU6-1207P. Each is linked with TPST1 in more than 1 cancer types. Because this analysis shows association rather than direction, both TPST1-to-partner and partner-to-TPST1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU1-17P grouped by TPST1-low versus TPST1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TPST1→partner) and Y-score (partner→TPST1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNU1-17P →	+0.235	+2.557	<.001	.003	3	2
UCEC	RNU6-1060P →	+0.252	+2.814	.006	.003	3	2
SKCM	RNU6-1207P →	+0.266	+5.039	<.001	.003	3	2
UCEC	ZNF215 →	+0.536	+2.332	.003	.003	3	1
UCEC	GRIK4 →	-0.450	-3.443	.009	.005	3	1
UCEC	GPATCH11 →	+0.461	+2.332	.003	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 748 associations by consensus.

RNU1-17P by TPST1 expression — UCEC

Explore this box plot interactively →