TPST1

Across TCGA patient cohorts, TPST1 mutation is significantly associated with the total protein of many other genes, with 21 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TPST1-associated genes across cancer lineages are EGFR_pY1068, INPP4B, and MEK1. Each is linked with TPST1 in more than 1 cancer types. Because this analysis shows association rather than direction, both TPST1-to-partner and partner-to-TPST1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by TPST1-low versus TPST1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TPST1→partner) and Y-score (partner→TPST1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.316	-3.700	.006	.001	3	1
UCEC	INPP4B →	-0.309	-3.321	.040	.009	3	1
UCEC	MEK1 →	+0.436	+3.321	.010	.010	3	1
UCEC	p62 Lck ligand →	+0.384	+2.179	.011	.034	3	1
UCEC	p70-S6K_pT389 →	-0.226	-3.169	.010	.018	3	1
UCEC	PDCD4 →	-0.525	-2.999	.016	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 21 associations by consensus.

EGFR_pY1068 by TPST1 expression — UCEC

Explore this box plot interactively →