TPSG1

Across TCGA cell cohorts, TPSG1 mutation is significantly associated with the mutation status of many other genes, with 1,024 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TPSG1-associated genes across cancer lineages are POLR2B, SBNO2, and NBN. Each is linked with TPSG1 in more than 2 cancer types. Because this analysis shows association rather than direction, both TPSG1-to-partner and partner-to-TPSG1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, POLR2B grouped by TPSG1-low versus TPSG1-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TPSG1→partner) and Y-score (partner→TPSG1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	POLR2B →	+4.187	+5.000	.008	.008	1	3
BREAST	SBNO2 →	+5.297	+5.297	.004	.004	1	2
BLOOD_Leukemia	NBN →	+4.321	+5.285	.005	.005	1	2
LUNG_NSCLC_LUAD	RANGAP1 →	+4.187	+5.000	.008	.008	1	2
LUNG_NSCLC_LUAD	DPYSL3 →	+4.187	+5.000	.008	.008	1	2
BLOOD_Lymphoma	CLCC1 →	+5.584	+5.014	.003	.003	1	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,024 associations by consensus.

POLR2B by TPSG1 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →