TPSD1

Across TCGA cell cohorts, TPSD1 mutation is significantly associated with the RNA expression of many other genes, with 40 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible TPSD1-associated genes across cancer lineages are FAM118A, SOX6, and EML4. Each is linked with TPSD1 in more than 1 cancer types. Because this analysis shows association rather than direction, both TPSD1-to-partner and partner-to-TPSD1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FAM118A grouped by TPSD1-low versus TPSD1-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TPSD1→partner) and Y-score (partner→TPSD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	FAM118A →	+1.102	+3.212	<.001	.006	3	1
SKIN	SOX6 →	+1.347	+3.212	.005	.006	3	1
SKIN	EML4 →	+0.519	+3.212	.001	.006	3	1
SKIN	HABP2 →	+0.110	+2.714	.003	.008	3	1
SKIN	PPBP →	+0.096	+2.347	.006	.007	3	1
SKIN	AHCYL1 →	+0.680	+3.212	.007	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 40 associations by consensus.

FAM118A by TPSD1 expression — SKIN

Explore this box plot interactively →