TPRXL

Across TCGA patient cohorts, TPRXL mutation is significantly associated with the RNA expression of many other genes, with 13 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TPRXL-associated genes across cancer lineages are BCRP9, RN7SL478P, and RNU4-13P. Each is linked with TPRXL in more than 1 cancer types. Because this analysis shows association rather than direction, both TPRXL-to-partner and partner-to-TPRXL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, BCRP9 grouped by TPRXL-low versus TPRXL-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TPRXL→partner) and Y-score (partner→TPRXL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	BCRP9 →	+0.287	+2.871	.006	.007	3	1
UCEC	RN7SL478P →	+0.330	+2.676	<.001	.007	3	1
UCEC	RNU4-13P →	+0.168	+4.242	<.001	.006	3	1
UCEC	RNU6-1296P →	+0.238	+4.662	<.001	.003	3	1
UCEC	MIR596 →	+0.681	+2.902	<.001	.006	3	1
UCEC	IGHD3-9 →	+1.543	+2.567	.006	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

BCRP9 by TPRXL expression — UCEC

Explore this box plot interactively →