TPRXL

Across TCGA cell cohorts, TPRXL mutation is significantly associated with the RNA expression of many other genes, with 4 significant associations in total. BREAST shows the largest number of these associations.

The most reproducible TPRXL-associated genes across cancer lineages are MYL1, TEX43, and C1orf185. Each is linked with TPRXL in more than 1 cancer types. Because this analysis shows association rather than direction, both TPRXL-to-partner and partner-to-TPRXL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MYL1 grouped by TPRXL-low versus TPRXL-high in BREAST.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TPRXL→partner) and Y-score (partner→TPRXL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	MYL1 →	+0.114	+3.963	<.001	.003	3	1
BREAST	TEX43 →	+0.111	+3.672	<.001	.006	3	1
BREAST	C1orf185 →	+0.040	+4.196	<.001	.006	3	1
BREAST	OOSP3 →	+0.084	+3.758	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

MYL1 by TPRXL expression — BREAST

Explore this box plot interactively →