TPRG1L

Across TCGA pan-cancer cohorts, TPRG1L mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated TPRG1L data layer compared with 21 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher TPRG1L mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated TPRG1L expression acts as an unfavorable survival marker, although some lineages such as HNSC and PDAC show a favorable association.

HNSC, PDAC, and LUAD are the cancer types where TPRG1L mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	All	0.861	0.679	.006	35	view →
PDAC	DFS	Median	All	0.844	0.680	.001	23	view →
LUAD	DFS	Tertile	II,III,IV	0.240	0.795	<.001	21	view →
CCRCC	DFS	Tertile	II,III,IV	0.979	0.725	.019	3	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

TPRG1L–HNSC (DFS)

Open the HNSC breakdown →