TPRG1L

Across TCGA patient cohorts, TPRG1L mutation is significantly associated with the total protein of many other genes, with 13 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TPRG1L-associated genes across cancer lineages are ERK2, STAT3_pY705, and Syk. Each is linked with TPRG1L in more than 1 cancer types. Because this analysis shows association rather than direction, both TPRG1L-to-partner and partner-to-TPRG1L results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ERK2 grouped by TPRG1L-low versus TPRG1L-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TPRG1L→partner) and Y-score (partner→TPRG1L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ERK2 →	+0.219	+2.321	.023	.035	3	1
UCEC	STAT3_pY705 →	-0.468	-2.321	<.001	.035	3	1
UCEC	Syk →	+0.405	+3.472	.031	.002	3	1
UCEC	TAZ →	-0.140	-2.990	.049	.036	3	1
UCEC	VHL →	-1.139	-2.321	<.001	.035	3	1
UCEC	ASNS →	+0.522	+3.000	.004	.036	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

ERK2 by TPRG1L expression — UCEC

Explore this box plot interactively →