Across TCGA pan-cancer cohorts, TPRG1 Mutation is linked to patient survival in 4 of 34 cancer types, making it a survival-associated TPRG1 data layer compared with 24 for mass-spec protein and 2 for mass-spec protein.

The strongest signal is observed in cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC), where higher TPRG1 Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated TPRG1 expression acts as an unfavorable survival marker, although some lineages such as SKCM show a favorable association.

CESC, COAD, and LUSC are the cancer types where TPRG1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CESC	DFS	Median	All	0.053	0.823	<.001	42	view →
COAD	OS	Median	All	0.140	0.871	<.001	21	view →
LUSC	OS	Median	III,IV	0.112	0.664	.003	12	view →
SKCM	OS	Median	All	1.000	0.866	.013	7	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

Exploration

Same gene, other analysis: TPRG1 tumor-vs-normal RNA expression · all TPRG1 data types