Across TCGA patient cohorts, TPRG1 mutation is significantly associated with the RNA expression of many other genes, with 1,337 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TPRG1-associated genes across cancer lineages are KIAA0586, SETD6, and TMEM33. Each is linked with TPRG1 in more than 1 cancer types. Because this analysis shows association rather than direction, both TPRG1-to-partner and partner-to-TPRG1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TPRG1→partner) and Y-score (partner→TPRG1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	KIAA0586 →	+0.403	+3.202	.007	.009	3	2
SKCM	SETD6 →	+0.503	+2.913	.002	.001	3	2
UCEC	TMEM33 →	+0.695	+3.467	.001	.002	3	2
SKCM	TTF2 →	+0.598	+2.964	.002	<.001	3	2
UCEC	PDS5A →	+0.572	+2.617	.006	.006	3	2
UCEC	CLCC1 →	+0.644	+3.609	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,337 associations by consensus.

Exploration

TPRG1 survival (RNA) · tumor vs normal (RNA) · all TPRG1 data types