Across TCGA patient cohorts, TPRG1 mutation is significantly associated with the total protein of many other genes, with 8 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TPRG1-associated genes across cancer lineages are p62 Lck ligand, PCNA, and SLC1A5. Each is linked with TPRG1 in more than 1 cancer types. Because this analysis shows association rather than direction, both TPRG1-to-partner and partner-to-TPRG1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TPRG1→partner) and Y-score (partner→TPRG1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p62 Lck ligand →	+0.441	+3.459	.006	.005	3	1
UCEC	PCNA →	+0.292	+2.321	.007	.035	3	1
UCEC	SLC1A5 →	-0.501	-2.314	.019	.035	3	1
UCEC	INPP4B →	-0.351	-3.000	.030	.036	2	1
UCEC	Notch1 →	+0.204	+3.009	.003	.019	2	1
UCEC	Tuberin →	+0.318	+2.321	.018	.035	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

Exploration

TPRG1 survival (RNA) · tumor vs normal (RNA) · all TPRG1 data types