TPR

Across TCGA patient cohorts, TPR mutation is significantly associated with the RNA expression of many other genes, with 5,808 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TPR-associated genes across cancer lineages are ECHS1, COX5A, and ANXA2. Each is linked with TPR in more than 4 cancer types. Because this analysis shows association rather than direction, both TPR-to-partner and partner-to-TPR results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ECHS1 grouped by TPR-low versus TPR-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TPR→partner) and Y-score (partner→TPR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	ECHS1 →	+0.548	+3.471	.001	.002	3	5
UCEC	COX5A →	+0.321	+2.148	<.001	<.001	3	5
UCEC	ANXA2 →	+0.434	+1.936	.001	.002	3	5
BRCA	PRICKLE2 →	-1.074	-3.459	<.001	.005	3	4
BRCA	CXCL10 →	+1.749	+3.334	<.001	.005	3	4
SKCM	ATP1B2 →	-1.414	-3.681	.003	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,808 associations by consensus.

ECHS1 by TPR expression — STAD

Explore this box plot interactively →