TPR

Across TCGA patient cohorts, TPR mutation is significantly associated with the total protein of many other genes, with 82 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TPR-associated genes across cancer lineages are mTOR_pS2448, TIGAR, and 4E-BP1_pS65. Each is linked with TPR in more than 5 cancer types. Because this analysis shows association rather than direction, both TPR-to-partner and partner-to-TPR results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, mTOR_pS2448 grouped by TPR-low versus TPR-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TPR→partner) and Y-score (partner→TPR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	mTOR_pS2448 →	-0.231	-2.446	.003	.018	3	6
LUAD	TIGAR →	+0.186	+2.807	.042	.003	3	4
LUSC	4E-BP1_pS65 →	+0.134	+1.888	.014	.028	3	4
STAD	4E-BP1 →	+0.367	+3.169	.006	.018	3	4
STAD	PKC-b-II_pS660 →	-0.493	-2.978	.001	.033	3	4
STAD	ATM →	-0.564	-2.321	.001	.034	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 82 associations by consensus.

mTOR_pS2448 by TPR expression — LUAD

Explore this box plot interactively →