TPR

Across TCGA cell cohorts, TPR RNA expression is significantly associated with the go_rna of many other GO terms, with 3,637 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible TPR-associated GO terms across cancer lineages are Positive regulation of chromatin organization, Mitotic G2/M transition checkpoint, and Negative regulation of gene expression, epigenetic. Each is linked with TPR in more than 19 cancer types. Because this analysis shows association rather than direction, both TPR-to-partner and partner-to-TPR results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of chromatin organization grouped by TPR-low versus TPR-high in LUNG_SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TPR→partner) and Y-score (partner→TPR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	Positive regulation of chromatin organization →	+0.186	+1.037	<.001	<.001	3	20
UPPER_AERODIGESTIVE_TRACT	Mitotic G2/M transition checkpoint →	+0.122	+1.085	<.001	<.001	3	18
UPPER_AERODIGESTIVE_TRACT	Negative regulation of gene expression, epigenetic →	+0.067	+1.052	<.001	<.001	3	18
URINARY_TRACT	Centrosome duplication →	+0.102	+0.846	.001	.002	3	18
UPPER_AERODIGESTIVE_TRACT	DNA recombination →	+0.059	+0.672	<.001	<.001	3	18
UPPER_AERODIGESTIVE_TRACT	Recombinational repair →	+0.074	+0.850	<.001	<.001	3	17

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,637 associations by consensus.

Positive regulation of chromatin organization by TPR expression — LUNG_SCLC

Explore this box plot interactively →