TPR

Across TCGA cell cohorts, TPR mutation is significantly associated with the RNA expression of many other genes, with 1,485 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TPR-associated genes across cancer lineages are FBXO28, FBXW7, and RELCH. Each is linked with TPR in more than 2 cancer types. Because this analysis shows association rather than direction, both TPR-to-partner and partner-to-TPR results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FBXO28 grouped by TPR-low versus TPR-high in BREAST.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TPR→partner) and Y-score (partner→TPR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	FBXO28 →	+0.598	+3.220	.009	.005	3	3
LARGE_INTESTINE	FBXW7 →	+0.547	+2.290	<.001	<.001	3	3
LARGE_INTESTINE	RELCH →	+0.706	+1.906	<.001	.001	3	3
LARGE_INTESTINE	MAMDC4 →	+0.751	+2.000	<.001	.009	3	3
LARGE_INTESTINE	PMS1 →	+0.362	+1.545	.005	.004	3	3
PANCREAS	HTR1A →	+0.004	+3.139	<.001	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,485 associations by consensus.

FBXO28 by TPR expression — BREAST

Explore this box plot interactively →