TPPP3

Across TCGA pan-cancer cohorts, TPPP3 mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated TPPP3 data layer compared with 27 for mass-spec protein and 1 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher TPPP3 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated TPPP3 expression acts as an unfavorable survival marker, although some lineages such as PDAC and CCRCC show a favorable association.

PDAC, CCRCC, and LSCC are the cancer types where TPPP3 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	DFS	Quartile	All	0.538	0.259	<.001	75	view →
CCRCC	DFS	Tertile	III,IV	0.858	0.469	.005	28	view →
LSCC	DFS	Median	All	0.601	0.826	.003	21	view →
UCEC	OS	Quartile	II,III,IV	0.519	1.000	.040	8	view →
COAD	DFS	Median	IV	1.000	0.605	.043	6	view →
GBM	OS	Tertile	All	0.814	0.942	.028	2	view →
HNSC	DFS	Median	IV	0.870	0.685	.049	1	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

TPPP3–PDAC (DFS)

Open the PDAC breakdown →