TPPP3

Across TCGA patient cohorts, TPPP3 mutation is significantly associated with the RNA expression of many other genes, with 104 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TPPP3-associated genes across cancer lineages are RNU6-660P, MIR98, and TRBV11-3. Each is linked with TPPP3 in more than 1 cancer types. Because this analysis shows association rather than direction, both TPPP3-to-partner and partner-to-TPPP3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-660P grouped by TPPP3-low versus TPPP3-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TPPP3→partner) and Y-score (partner→TPPP3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	RNU6-660P →	+0.367	+6.018	<.001	.002	3	1
UCEC	MIR98 →	+0.318	+2.994	.001	.003	3	1
UCEC	TRBV11-3 →	+0.445	+2.657	<.001	.005	3	1
UCEC	RNA5SP412 →	+0.663	+2.704	.001	.004	3	1
UCEC	MIR6856 →	+0.495	+2.792	<.001	.006	3	1
SKCM	OR4K4P →	+0.089	+7.816	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 104 associations by consensus.

RNU6-660P by TPPP3 expression — BLCA

Explore this box plot interactively →