TPPP3

Across TCGA patient cohorts, TPPP3 mutation is significantly associated with the total protein of many other genes, with 11 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TPPP3-associated genes across cancer lineages are YAP, IGFBP2, and Ku80. Each is linked with TPPP3 in more than 1 cancer types. Because this analysis shows association rather than direction, both TPPP3-to-partner and partner-to-TPPP3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, YAP grouped by TPPP3-low versus TPPP3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TPPP3→partner) and Y-score (partner→TPPP3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	YAP →	+0.173	+2.820	.035	.035	3	2
UCEC	IGFBP2 →	-0.775	-3.169	.029	.020	3	1
UCEC	Ku80 →	+0.299	+3.183	.021	.010	3	1
UCEC	MEK1 →	+0.652	+3.169	.001	.020	3	1
UCEC	p21 →	+0.256	+3.169	.015	.020	3	1
UCEC	p62 Lck ligand →	+0.469	+3.009	.008	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

YAP by TPPP3 expression — UCEC

Explore this box plot interactively →