TPP2

Across TCGA cell cohorts, TPP2 mutation is significantly associated with the RNA expression of many other genes, with 254 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TPP2-associated genes across cancer lineages are OR56A4, OR56A5, and PPP1R2C. Each is linked with TPP2 in more than 1 cancer types. Because this analysis shows association rather than direction, both TPP2-to-partner and partner-to-TPP2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR56A4 grouped by TPP2-low versus TPP2-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TPP2→partner) and Y-score (partner→TPP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	OR56A4 →	+0.157	+3.362	<.001	.007	3	2
LUNG_NSCLC_LUAD	OR56A5 →	+0.060	+3.887	<.001	.002	3	2
BLOOD_Myeloma	PPP1R2C →	+0.036	+4.807	<.001	.006	3	1
BLOOD_Myeloma	GAST →	+0.060	+4.807	<.001	.006	3	1
LUNG_SCLC	APCS →	+0.042	+4.643	<.001	.004	3	1
LUNG_SCLC	PRR23B →	+0.005	+4.643	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 254 associations by consensus.

OR56A4 by TPP2 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →