TPP2

Across TCGA cell cohorts, TPP2 mutation is significantly associated with the mutation status of many other genes, with 5,034 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TPP2-associated genes across cancer lineages are AP2A1, GON4L, and PPFIA2. Each is linked with TPP2 in more than 5 cancer types. Because this analysis shows association rather than direction, both TPP2-to-partner and partner-to-TPP2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, AP2A1 grouped by TPP2-low versus TPP2-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TPP2→partner) and Y-score (partner→TPP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	AP2A1 →	+4.063	+3.584	.003	.003	1	6
BLOOD_Lymphoma	GON4L →	+3.584	+4.922	.001	.001	1	5
BLOOD_Leukemia	PPFIA2 →	+2.728	+3.375	.003	.003	1	5
PANCREAS	MED12L →	+5.115	+5.115	.005	.005	1	4
PANCREAS	MTOR →	+5.115	+5.115	.005	.005	1	4
BLOOD_Lymphoma	AP2B1 →	+5.169	+5.832	<.001	<.001	1	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,034 associations by consensus.

AP2A1 by TPP2 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →