TPP1

Across TCGA pan-cancer cohorts, TPP1 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated TPP1 data layer compared with 26 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher TPP1 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated TPP1 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and LSCC show a favorable association.

UCEC, LUAD, and COAD are the cancer types where TPP1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Tertile	III,IV	0.352	1.000	.013	30	view →
LUAD	OS	Tertile	All	0.552	0.879	.008	27	view →
COAD	DFS	Median	III,IV	0.829	1.000	.027	18	view →
CCRCC	DFS	Median	II,III,IV	1.000	0.301	.006	14	view →
PDAC	DFS	Quartile	III,IV	0.370	0.907	.010	9	view →
LSCC	OS	Tertile	III,IV	0.943	0.542	.032	2	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

TPP1–UCEC (DFS)

Open the UCEC breakdown →