TPP1

Across TCGA pan-cancer cohorts, TPP1 mass-spec protein differs between tumor and matched normal tissue in 6 of 18 cancer types tested, making tumor–normal expression one of TPP1’s most consistent transcriptional readouts.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where TPP1 mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types TPP1 is over-expressed in tumor, although a few such as LSCC and LUAD show the opposite, repressed pattern.

LSCC, LUAD, and HNSC are the cancer types where TPP1 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TPP1 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LSCC	Female	All	−0.889	<.001	8	view →
LUAD	Male	All	−0.503	<.001	8	view →
HNSC	All	III,IV	−0.229	<.001	8	view →
PDAC	Female	All	+0.662	<.001	6	view →
CCRCC	Male	II,III,IV	+0.192	.002	6	view →
COAD	All	All	−0.130	.002	5	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 6 strongest of 6 lineages.

TPP1–LSCC

Open the LSCC breakdown →