TPP1

Across TCGA patient cohorts, TPP1 protein abundance is significantly associated with the RNA expression of many other genes, with 15,201 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible TPP1-associated genes across cancer lineages are GRAP2, CXCL12, and TMEM97. Each is linked with TPP1 in more than 5 cancer types. Because this analysis shows association rather than direction, both TPP1-to-partner and partner-to-TPP1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, TPP1 versus GRAP2 in OV, with a Pearson correlation of 0.39.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TPP1→partner) and Y-score (partner→TPP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	GRAP2 →	+0.712	+0.375	<.001	.003	3	6
LSCC	CXCL12 →	+0.914	+0.414	<.001	<.001	3	6
HNSC	TMEM97 →	-1.018	-0.329	<.001	<.001	3	6
GBM	PARVG →	+0.832	+0.330	<.001	<.001	3	6
OV	DAB2 →	+0.961	+0.455	.001	.001	3	6
HNSC	IL16 →	+0.740	+0.431	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 15,201 associations by consensus.

TPP1 vs GRAP2 — OV

Explore this scatter interactively →