TPP1

Across TCGA patient cohorts, TPP1 mutation is significantly associated with the RNA expression of many other genes, with 1,119 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TPP1-associated genes across cancer lineages are SCP2D1, LINC00158, and RNA5SP447. Each is linked with TPP1 in more than 2 cancer types. Because this analysis shows association rather than direction, both TPP1-to-partner and partner-to-TPP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SCP2D1 grouped by TPP1-low versus TPP1-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TPP1→partner) and Y-score (partner→TPP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	SCP2D1 →	+0.062	+4.678	<.001	.003	3	3
COAD	LINC00158 →	+0.290	+3.584	<.001	.006	3	2
COAD	RNA5SP447 →	+0.341	+4.821	<.001	.003	3	2
COAD	SNORD31B →	+0.753	+4.399	<.001	.006	3	2
COAD	MIR500A →	+0.457	+4.399	<.001	.006	3	2
BRCA	TRGV11 →	+0.251	+4.270	<.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,119 associations by consensus.

SCP2D1 by TPP1 expression — SKCM

Explore this box plot interactively →