TPP1

Across TCGA patient cohorts, TPP1 mutation is significantly associated with the total protein of many other genes, with 20 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TPP1-associated genes across cancer lineages are INPP4B, MEK1, and PCNA. Each is linked with TPP1 in more than 1 cancer types. Because this analysis shows association rather than direction, both TPP1-to-partner and partner-to-TPP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, INPP4B grouped by TPP1-low versus TPP1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TPP1→partner) and Y-score (partner→TPP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	INPP4B →	-0.338	-2.415	.004	.003	3	2
UCEC	MEK1 →	+0.353	+1.906	.008	.015	3	2
UCEC	PCNA →	+0.250	+2.736	.001	<.001	3	2
UCEC	PTEN →	-0.338	-1.502	.020	.030	3	2
UCEC	ATM →	-0.411	-1.847	.013	.008	3	2
UCEC	EGFR_pY1068 →	-0.267	-2.247	.003	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 20 associations by consensus.

INPP4B by TPP1 expression — UCEC

Explore this box plot interactively →