TPP1

Across TCGA cell cohorts, TPP1 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,783 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible TPP1-associated GO terms across cancer lineages are Glycolipid catabolic process, Negative regulation of respiratory burst involved in inflammatory response, and Negative regulation of respiratory burst. Each is linked with TPP1 in more than 15 cancer types. Because this analysis shows association rather than direction, both TPP1-to-partner and partner-to-TPP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Glycolipid catabolic process grouped by TPP1-low versus TPP1-high in SOFT_TISSUE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TPP1→partner) and Y-score (partner→TPP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	Glycolipid catabolic process →	+0.195	+1.215	<.001	<.001	3	16
KIDNEY	Negative regulation of respiratory burst involved in inflammatory response →	+0.165	+1.231	.001	.001	3	16
KIDNEY	Negative regulation of respiratory burst →	+0.165	+1.231	.001	.001	3	16
LUNG_SCLC	Membrane protein proteolysis →	+0.148	+1.407	<.001	<.001	3	14
BONE	Protein localization to endosome →	+0.164	+1.234	.009	.001	2	15
PANCREAS	ERAD pathway →	+0.081	+0.959	<.001	<.001	3	14

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,783 associations by consensus.

Glycolipid catabolic process by TPP1 expression — SOFT_TISSUE

Explore this box plot interactively →