TPP1

Across TCGA cell cohorts, TPP1 mutation is significantly associated with the mutation status of many other genes, with 5,489 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TPP1-associated genes across cancer lineages are MAGI2, PRKG1, and DROSHA. Each is linked with TPP1 in more than 3 cancer types. Because this analysis shows association rather than direction, both TPP1-to-partner and partner-to-TPP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MAGI2 grouped by TPP1-low versus TPP1-high in OVARY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TPP1→partner) and Y-score (partner→TPP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	MAGI2 →	+3.562	+4.684	.002	.002	1	4
BLOOD_Leukemia	PRKG1 →	+4.000	+5.050	.008	.008	1	4
LARGE_INTESTINE	DROSHA →	+2.155	+3.392	<.001	<.001	1	4
OVARY	DZIP1 →	+4.977	+4.415	.007	.007	1	4
LARGE_INTESTINE	DAB2IP →	+3.222	+5.050	<.001	<.001	1	4
SKIN	MAB21L3 →	+5.824	+5.824	.002	.002	1	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,489 associations by consensus.

MAGI2 by TPP1 expression — OVARY

Explore this box plot interactively →