TPP1

Across TCGA cell cohorts, TPP1 mutation is significantly associated with the drug of many other genes, with 22 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TPP1-associated genes across cancer lineages are Mirin, GSK1904529A, and Uprosertib. Each is linked with TPP1 in more than 1 cancer types. Because this analysis shows association rather than direction, both TPP1-to-partner and partner-to-TPP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Mirin grouped by TPP1-low versus TPP1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TPP1→partner) and Y-score (partner→TPP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	Mirin →	+0.524	+2.646	.004	.047	3	1
LARGE_INTESTINE	GSK1904529A →	+0.369	+2.769	.027	.040	3	1
LARGE_INTESTINE	Uprosertib →	+0.627	+2.646	.038	.047	2	2
LARGE_INTESTINE	Zibotentan →	+0.233	+2.652	.021	.045	3	1
LARGE_INTESTINE	ETP-45835 →	+0.277	+2.652	.021	.045	3	1
LARGE_INTESTINE	CD532 →	+0.475	+2.652	.017	.045	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 22 associations by consensus.

Mirin by TPP1 expression — LARGE_INTESTINE

Explore this box plot interactively →