TPO

Across TCGA patient cohorts, TPO RNA expression is significantly associated with the protein abundance of many other proteins, with 13,122 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible TPO-associated proteins across cancer lineages are VPS13C, VWF, and YRDC_S37. Each is linked with TPO in more than 3 cancer types. Because this analysis shows association rather than direction, both TPO-to-partner and partner-to-TPO results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, TPO versus VPS13C in BRCA, with a Pearson correlation of 0.37.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (TPO→partner) and Y-score (partner→TPO) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	VPS13C →	+0.298	+0.601	<.001	<.001	3	4
CCRCC	VWF →	+0.544	+0.118	<.001	.006	3	4
PDAC	YRDC_S37 →	-0.423	-0.216	<.001	.001	3	4
BRCA	SEPTIN4_S117 →	+0.918	+0.848	<.001	<.001	3	4
HNSC	SPARCL1_S198 →	+0.909	+0.624	<.001	<.001	3	4
HNSC	CAVIN2_S203 →	+0.852	+0.652	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 13,122 associations by consensus.

TPO vs VPS13C — BRCA

Explore this scatter interactively →