TPO

Across TCGA patient cohorts, TPO mutation is significantly associated with the total protein of many other genes, with 71 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TPO-associated genes across cancer lineages are PCNA, Caspase-7-cleavedD198, and Beclin. Each is linked with TPO in more than 3 cancer types. Because this analysis shows association rather than direction, both TPO-to-partner and partner-to-TPO results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PCNA grouped by TPO-low versus TPO-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TPO→partner) and Y-score (partner→TPO) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	PCNA →	+0.292	+3.321	.006	.008	3	4
COAD	Caspase-7-cleavedD198 →	+1.356	+2.230	<.001	.006	3	4
STAD	Beclin →	-0.185	-2.321	.021	.032	3	3
STAD	c-Kit →	-0.325	-1.874	.005	.045	3	3
STAD	Cyclin-B1 →	+0.435	+1.807	.011	.025	3	3
CESC	PKC-b-II_pS660 →	-0.560	-3.000	.020	.033	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 71 associations by consensus.

PCNA by TPO expression — STAD

Explore this box plot interactively →