TPO

Across TCGA cell cohorts, TPO RNA expression is significantly associated with the go_rna of many other GO terms, with 2,143 significant associations in total. BREAST shows the largest number of these associations.

The most reproducible TPO-associated GO terms across cancer lineages are Protein exit from endoplasmic reticulum, Foam cell differentiation, and Negative regulation of bone mineralization involved in bone maturation. Each is linked with TPO in more than 4 cancer types. Because this analysis shows association rather than direction, both TPO-to-partner and partner-to-TPO results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Protein exit from endoplasmic reticulum grouped by TPO-low versus TPO-high in OESOPHAGUS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TPO→partner) and Y-score (partner→TPO) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	Protein exit from endoplasmic reticulum →	+0.104	+0.141	.003	.004	3	5
BREAST	Foam cell differentiation →	-0.347	-0.809	<.001	<.001	3	5
BREAST	Negative regulation of bone mineralization involved in bone maturation →	-0.994	-0.497	<.001	.002	3	5
BREAST	Humoral immune response mediated by circulating immunoglobulin →	-0.270	-0.644	<.001	<.001	3	5
BREAST	Negative regulation of chondrocyte development →	-1.076	-0.841	<.001	<.001	3	5
OVARY	Negative regulation of natural killer cell mediated immune response to tumor cell →	-1.099	-0.192	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,143 associations by consensus.

Protein exit from endoplasmic reticulum by TPO expression — OESOPHAGUS

Explore this box plot interactively →