TPO

Across TCGA cell cohorts, TPO mutation is significantly associated with the RNA expression of many other genes, with 437 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TPO-associated genes across cancer lineages are ZNF57, OR52B2, and HHLA1. Each is linked with TPO in more than 2 cancer types. Because this analysis shows association rather than direction, both TPO-to-partner and partner-to-TPO results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ZNF57 grouped by TPO-low versus TPO-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TPO→partner) and Y-score (partner→TPO) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ZNF57 →	+0.411	+1.949	.002	.002	3	3
SOFT_TISSUE	OR52B2 →	+0.041	+4.882	<.001	.001	3	2
BLOOD_Leukemia	HHLA1 →	+0.005	+2.703	<.001	.002	3	2
BLOOD_Leukemia	EDA →	+0.818	+3.662	<.001	.001	3	2
BLOOD_Leukemia	GPR101 →	+0.063	+2.703	<.001	.002	3	2
SKIN	PRKD2 →	-0.415	-3.278	.004	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 437 associations by consensus.

ZNF57 by TPO expression — LARGE_INTESTINE

Explore this box plot interactively →