TPMTP1

Across TCGA patient cohorts, TPMTP1 RNA expression is significantly associated with the go_rna of many other GO terms, with 6,793 significant associations in total. THCA shows the largest number of these associations.

The most reproducible TPMTP1-associated GO terms across cancer lineages are 5S class rRNA transcription by RNA polymerase III, Rescue of stalled ribosome, and Membrane fission. Each is linked with TPMTP1 in more than 19 cancer types. Because this analysis shows association rather than direction, both TPMTP1-to-partner and partner-to-TPMTP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 5S class rRNA transcription by RNA polymerase III grouped by TPMTP1-low versus TPMTP1-high in ACC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TPMTP1→partner) and Y-score (partner→TPMTP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
ACC	5S class rRNA transcription by RNA polymerase III →	+0.070	+0.488	<.001	<.001	3	19
THYM	Rescue of stalled ribosome →	+0.069	+0.280	<.001	<.001	1	20
STAD	Membrane fission →	+0.042	+0.156	<.001	.001	1	20
ACC	Positive regulation of rRNA processing →	+0.046	+0.614	<.001	<.001	3	18
THYM	Maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) →	+0.047	+0.227	<.001	<.001	3	18
ESCA	Vesicle cargo loading →	+0.076	+0.240	<.001	<.001	3	18

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,793 associations by consensus.

5S class rRNA transcription by RNA polymerase III by TPMTP1 expression — ACC

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