TPMT

Across TCGA patient cohorts, TPMT RNA expression is significantly associated with the RNA expression of many other genes, with 19,768 significant associations in total. UVM shows the largest number of these associations.

The most reproducible TPMT-associated genes across cancer lineages are TDP2, KDM1B, and HMGN4. Each is linked with TPMT in more than 32 cancer types. Because this analysis shows association rather than direction, both TPMT-to-partner and partner-to-TPMT results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, TPMT versus TDP2 in UVM, with a Pearson correlation of 0.87.

RNA expression associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TPMT→partner) and Y-score (partner→TPMT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UVM	TDP2 →	+1.240	+1.265	<.001	<.001	3	33
UVM	KDM1B →	+1.290	+1.219	<.001	<.001	3	32
UVM	HMGN4 →	+1.317	+1.242	<.001	<.001	3	32
UVM	SEC22B →	+1.264	+1.231	<.001	<.001	3	32
UVM	PAK1IP1 →	+1.718	+1.288	<.001	<.001	3	32
UVM	MRPL19 →	+1.169	+1.377	<.001	<.001	3	32

Each partner links to its Q-omics profile. Showing the 6 strongest of 19,768 associations by consensus.

TPMT vs TDP2 — UVM

Explore this scatter interactively →