TPMT

Across TCGA patient cohorts, TPMT protein abundance is significantly associated with the RNA expression of many other genes, with 10,535 significant associations in total. GBM shows the largest number of these associations.

The most reproducible TPMT-associated genes across cancer lineages are KIF13A, KDM1B, and RIPK1. Each is linked with TPMT in more than 4 cancer types. Because this analysis shows association rather than direction, both TPMT-to-partner and partner-to-TPMT results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, TPMT versus KIF13A in BRCA, with a Pearson correlation of 0.40.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TPMT→partner) and Y-score (partner→TPMT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	KIF13A →	+0.713	+0.447	<.001	<.001	3	5
COAD	KDM1B →	+0.653	+0.486	<.001	<.001	3	5
OV	RIPK1 →	+0.529	+0.489	.001	.002	3	4
BRCA	FAM8A1 →	+0.519	+0.327	.002	.002	3	4
OV	PPP1R11 →	+0.555	+0.653	<.001	<.001	3	4
OV	ILRUN →	+0.483	+0.470	.002	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 10,535 associations by consensus.

TPMT vs KIF13A — BRCA

Explore this scatter interactively →