TPMT

Across TCGA cell cohorts, TPMT RNA expression is significantly associated with the go_rna of many other GO terms, with 5,318 significant associations in total. BONE shows the largest number of these associations.

The most reproducible TPMT-associated GO terms across cancer lineages are Vesicle transport along microtubule, Endosomal transport, and UDP-galactose transmembrane transport. Each is linked with TPMT in more than 8 cancer types. Because this analysis shows association rather than direction, both TPMT-to-partner and partner-to-TPMT results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Vesicle transport along microtubule grouped by TPMT-low versus TPMT-high in SOFT_TISSUE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TPMT→partner) and Y-score (partner→TPMT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	Vesicle transport along microtubule →	+0.062	+0.878	<.001	<.001	3	9
BONE	Endosomal transport →	+0.048	+1.152	.001	<.001	3	9
STOMACH	UDP-galactose transmembrane transport →	+0.118	+0.688	.001	<.001	3	9
BREAST	Regulation of stress granule assembly →	+0.098	+0.699	.002	.001	3	8
BLOOD_Lymphoma	Interleukin-9-mediated signaling pathway →	+0.199	+0.846	<.001	<.001	3	8
BLOOD_Lymphoma	Cellular response to interleukin-9 →	+0.199	+0.846	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,318 associations by consensus.

Vesicle transport along microtubule by TPMT expression — SOFT_TISSUE

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