TPM4

Across TCGA pan-cancer cohorts, TPM4 mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated TPM4 data layer compared with 26 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher TPM4 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated TPM4 expression acts as an unfavorable survival marker, although some lineages such as HNSC show a favorable association.

LSCC, COAD, and CCRCC are the cancer types where TPM4 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	OS	Tertile	All	0.687	0.928	.002	22	view →
COAD	DFS	Median	II,III,IV	0.879	1.000	.019	12	view →
CCRCC	OS	Median	II,III,IV	0.228	0.979	.003	10	view →
PDAC	DFS	Median	IV	0.214	0.785	.006	10	view →
GBM	DFS	Tertile	All	0.267	0.491	.018	9	view →
LUAD	DFS	Median	III,IV	0.325	0.732	.028	3	view →
HNSC	DFS	Tertile	II,III,IV	0.975	0.894	.048	1	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

TPM4–LSCC (OS)

Open the LSCC breakdown →