TPM4

Across TCGA cell cohorts, TPM4 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,688 significant associations in total. BONE shows the largest number of these associations.

The most reproducible TPM4-associated GO terms across cancer lineages are Regulation of protein processing, Positive regulation of supramolecular fiber organization, and Regulation of cell-matrix adhesion. Each is linked with TPM4 in more than 13 cancer types. Because this analysis shows association rather than direction, both TPM4-to-partner and partner-to-TPM4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of protein processing grouped by TPM4-low versus TPM4-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TPM4→partner) and Y-score (partner→TPM4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Regulation of protein processing →	+0.206	+1.693	<.001	<.001	3	14
BONE	Positive regulation of supramolecular fiber organization →	+0.116	+2.019	<.001	<.001	3	13
BONE	Regulation of cell-matrix adhesion →	+0.120	+1.327	<.001	<.001	3	13
BONE	Positive regulation of cell-matrix adhesion →	+0.214	+2.166	<.001	<.001	3	13
LUNG_NSCLC_LUSC	Collagen fibril organization →	+0.354	+1.607	<.001	.003	3	13
LUNG_NSCLC_LUSC	Wound healing →	+0.123	+1.498	<.001	.001	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,688 associations by consensus.

Regulation of protein processing by TPM4 expression — BONE

Explore this box plot interactively →