TPM4

Across TCGA cell cohorts, TPM4 mutation is significantly associated with the RNA expression of many other genes, with 4 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TPM4-associated genes across cancer lineages are DEFB132, ARMS2, and ELOA3DP. Each is linked with TPM4 in more than 1 cancer types. Because this analysis shows association rather than direction, both TPM4-to-partner and partner-to-TPM4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DEFB132 grouped by TPM4-low versus TPM4-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TPM4→partner) and Y-score (partner→TPM4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	DEFB132 →	+0.012	+5.029	<.001	.006	3	1
BLOOD_Leukemia	ARMS2 →	+0.033	+5.507	<.001	<.001	3	1
LARGE_INTESTINE	ELOA3DP →	+0.033	+4.688	<.001	<.001	3	1
LARGE_INTESTINE	OR6Q1 →	+0.018	+4.437	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

DEFB132 by TPM4 expression — LUNG_SCLC

Explore this box plot interactively →