TPM3P8

Across TCGA pan-cancer cohorts, TPM3P8 RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of TPM3P8’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where TPM3P8 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types TPM3P8 is over-expressed in tumor.

HNSC, BRCA, and COAD are the cancer types where TPM3P8 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TPM3P8 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	II,III,IV	+0.182	.001	8	view →
BRCA	All	III,IV	+0.253	<.001	6	view →
COAD	All	II,III,IV	+0.372	.003	5	view →
LIHC	Female	All	+0.115	<.001	5	view →
STAD	All	All	+0.438	.001	4	view →
UCEC	All	All	+0.350	.011	4	view →
LUAD	All	All	+0.341	<.001	4	view →
KIRC	All	All	+0.092	.001	4	view →
CHOL	All	All	+0.255	.001	2	view →
ESCA	All	All	+0.618	.015	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

TPM3P8–HNSC

Open the HNSC breakdown →