TPM3

Across TCGA patient cohorts, TPM3 mutation is significantly associated with the total protein of many other genes, with 26 significant associations in total. COAD shows the largest number of these associations.

The most reproducible TPM3-associated genes across cancer lineages are Annexin-1, Mre11, and MSH6. Each is linked with TPM3 in more than 1 cancer types. Because this analysis shows association rather than direction, both TPM3-to-partner and partner-to-TPM3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Annexin-1 grouped by TPM3-low versus TPM3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TPM3→partner) and Y-score (partner→TPM3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Annexin-1 →	+0.981	+3.341	<.001	.005	3	2
COAD	Mre11 →	+0.207	+3.008	<.001	.019	3	1
COAD	MSH6 →	-0.427	-2.974	.035	.036	3	1
COAD	p38-MAPK →	+0.200	+3.008	.027	.019	3	1
COAD	Rad50 →	-0.348	-2.991	.005	.036	3	1
COAD	Smad4 →	+0.191	+3.008	.005	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 26 associations by consensus.

Annexin-1 by TPM3 expression — UCEC

Explore this box plot interactively →